Effects of Subcutaneous Injection MnO2 Micro- and Nanoparticles on Blood Glucose Level and Lipid Profile in Rat

نویسندگان

  • Zahra Mousavi
  • Majid Hassanpourezatti
  • Parvaneh Najafizadeh
  • Shiva Rezagholian
  • Mohammad Safi Rhamanifar
  • Nahid Nosrati
چکیده

BACKGROUND The use of nanotechnology has led to rapid growth in various areas. Thus, health and safety issues of nanoparticles (NPs) should be promptly addressed. Manganese oxide (MnO2) nanoparticles (NPs) are typically used for biomedical and industrial applications. However, characterizing the potential human health effects of MnO2 NPs is required before fully exploiting these materials. The aim of this study was to investigate the toxicity of MnO2 micro- and nanoparticles on blood glucose level and lipid profile in male Wistar rats. METHODS A total of 105 rats were divided into one control and two experimental groups. Each experimental group received a single subcutaneous injection of MnO2 micro- and nanoparticles (100 μg/kg), respectively, every two weeks for 14 weeks. Their blood glucose, cholesterol, triglycerides, LDL, and HDL levels were then measured. The data presented as mean±SEM and compared with the repeated measures using the Prism statistical software (version 6.0). RESULTS Biochemical assessment in plasma samples showed that MnO2 micro- and nanoparticles injection significantly (P<0.01) increased the plasma glucose and cholesterol levels in all and few weeks, respectively. MnO2 nanoparticles significantly (P<0.01) decreased the HDL level in weeks 6, 12, and 14, but MnO2 microparticles decreased the HDL level only in week 12. In both MnO2 micro- and nanoparticles groups, LDL alterations were near to the control group, except for week 10. However, the same treatment had no effect on triglycerides concentrations compared to the control group. CONCLUSION Our results show that exposure to nanosized particles at subchronic doses caused adverse changes in animal biochemical profiles, especially in glucose level. It seems that the high oxidative power of these particles is the main reason for these disturbances.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of Subcutaneous Injection MnO2 Micro- and Nanoparticles on Blood Glucose Level and Lipid Profile in Rat

Background: The use of nanotechnology has led to rapid growth in various areas. Thus, health and safety issues of nanoparticles (NPs) should be promptly addressed. Manganese oxide (MnO2) nanoparticles (NPs) are typically used for biomedical and industrial applications. However, characterizing the potential human health effects of MnO2 NPs is required before fully exploiting these materials. The...

متن کامل

Comparison of MnO2 nanoparticles and microparticles distribution in CNS and muscle and effect on acute pain threshold in rats

Objective(s):   Recently, applications of MnO2 nanoparticles and microparticles in industry, pharmacology, and medicine have considerably expanded. Mn distribution and clearance from brain and spinal cord tissue compared with muscle tissue of rats after single subcutaneous injection of nanoparticles and microparticle of MnO2. Pain sensory threshold of rat was evaluated as neurologic consequence...

متن کامل

The effects of onion (Allium cepa L.) dried by different heat treatments on plasma lipid profile and fasting blood glucose level in diabetic rats

Objective: This study aims to evaluate the effects of onion (Allium cepa L.) against hyperglycaemia and dyslipidemia and determine possible changes in these effects due to different heat treatments applied to onion. Materials and Methods: 32 male Wistar-albino rats were divided into 4 groups as follows: the groups C and DC were fed with standard rat diet;...

متن کامل

The Effect of Foeniculum VULgare (Fennel) Extract on LIpid Profile, Lipid Peroxidation and Liver Enzymes of Diabetic Rat

Objective: Diabetes Mellitus (DM) is one of the leading causes of death, illness, and economic loss in the world. The present study was attempted to evaluate extract of Foeniculum vulgare (fennel) on lipid profile, lipid peroxidation and activities of amino transferase enzymes in streptozocin induced diabetic adult male rats. Materials and Methods: The effects of daily oral administration of...

متن کامل

Effect of Grape Seed Extract on Lipid Profile and Expression of Interleukin-6 in Polycystic Ovarian Syndrome Wistar Rat Model

Objective Polycystic ovary syndrome (PCOS) is a common but complex endocrine disorder and is the major cause of anovulation and consequent subfertility. In this study effect of GSE on TG, TC, HDL-C, LDL-C and IL-6 in PCOS Wistar rats were assessed. MaterialsAndMethods : In this experimental study, 84 adult female Wistar rats were divided into 7 groups (n=12) including control(intact), Sham(estr...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 41  شماره 

صفحات  -

تاریخ انتشار 2016